humanity’s requests for startups · v0.1

Infinite problems. Infinite solutions.

A live map for people with a moral mission — every company, founder, and economy pointed at 16 ranked problems worth your life. Find the good quest you are unusually positioned to carry, then start building.

The radar

Where demand is high, and supply is low.

Every problem ranked by opportunity: how badly the world needs a solution, divided by how well-served it already is. The biggest gaps are step zero.

01
Hypertension controlHealth
The largest controllable mortality risk is a primary-care delivery failure, not a missing drug.
0 cos · 0 funds on it
demand 57
dem
sup
60
02
Neglected tropical diseasesHealth
1.7 billion people need treatment for diseases that get under 2% of pharmaceutical R&D and falling aid.
0 cos · 0 funds on it · $20B prize
demand 81
dem
sup
48
03
Extreme povertyPovertyunderallocated
Lift the ~700 million people living on less than $2.15 a day into stable prosperity.
0 cos · 0 funds on it · $212B/yr · $500B prize
demand 90
dem
sup
47
04
Biosecurity & pandemic preparednessBiosecurityunderallocated
Prevent engineered and naturally-emerging pandemics from wiping out humanity or crippling civilization.
4 cos · 3 funds on it · $4B/yr · $200B prize
demand 86
dem
sup
44
05
AI datacenter powerEnergy
The AI compute buildout is no longer chip-constrained. It is power-constrained, and the gap is $1.3 trillion.
0 cos · 0 funds on it · $400B prize
demand 86
dem
sup
41
06
Newborn survivalHealth
2.3 million babies die in their first month of life every year, mostly from causes medicine already knows how to prevent.
0 cos · 0 funds on it · $30B prize
demand 68
dem
sup
35
07
Infectious disease (malaria, TB, HIV)Healthunderallocated
The Copenhagen Consensus welfare floor, pennies save lives, and we still are not spending them.
5 cos · 3 funds on it · $25B/yr · $200B prize
demand 86
dem
sup
22
08
Low-cost housing & constructionPovertyunderallocated
Close the gap between what materials cost and what buildings cost, housing is 5× its bill of materials.
5 cos · 5 funds on it · $10B/yr · $300B prize
demand 79
dem
sup
17
09
Loneliness & social isolationSocialunderallocated
The US Surgeon General called it an epidemic. Mortality effect equivalent to smoking 15 cigarettes a day.
4 cos · 1 funds on it · $300M/yr · $200B prize
demand 74
dem
sup
17
10
Climate changeClimateoverallocated
Decarbonize the global economy fast enough to limit warming, while keeping energy cheap and abundant.
0 cos · 0 funds on it · $1.5T/yr · $1T prize
demand 87
dem
sup
15
11
Financial infrastructureGovernance
Move value for everyone at near-zero cost, on rails not owned by a sixty-year-old duopoly.
0 cos · 0 funds on it · $1T prize
demand 80
dem
sup
14
12
Longevity & agingLongevityunderallocated
Extend healthspan. Aging is the single largest driver of disease burden, and it is treatable.
8 cos · 5 funds on it · $8B/yr · $3T prize
demand 82
dem
sup
11
13
Pedagogy at scaleEducationunderallocated
Close Bloom's 2-sigma gap, every child deserves a personal tutor, and AI may finally make it tractable.
5 cos · 4 funds on it · $3B/yr · $300B prize
demand 73
dem
sup
10
14
Fertility decline & demographic stagnationSocialunderallocated
Every developed country is below replacement. Under-counted by EA and e/acc. Civilizationally large.
4 cos · 1 funds on it · $1B/yr · $200B prize
demand 74
dem
sup
9
15
Scientific productivityScienceunderallocated
Ideas are getting harder to find. Reverse the decline in research productivity per dollar.
9 cos · 9 funds on it · $400M/yr · $1T prize
demand 73
dem
sup
5
16
Energy abundanceEnergyoverallocated
Produce clean, cheap, dispatchable energy at civilizational scale, fusion, advanced fission, geothermal.
34 cos · 13 funds on it · $2.2T/yr · $2T prize
demand 82
dem
sup
4

opportunity = demand (humans affected × severity × market) divided by supply (companies, capital, and solution quality already on it), nudged by urgency. Higher = a bigger, more urgent, less-served gap. The dots show how many independent demand signals (burden, willingness-to-pay, capital, research, policy, expert priors, queues & shortages) corroborate the number — more dots = more credible. allocation compares each problem’s share of real capital ($/yr, sourced estimates) to its share of demand: under half its fair share = underallocated, over double = overallocated. Arrows = 3-year capital momentum. Full method on the methodology page.

matched
16 / 16
humans affected
67.0B
lens
balanced
sorted by
priority
weighting: equal weight, all lenses
#problemtierco
01
Prevent engineered and naturally-emerging pandemics from wiping out humanity or crippling civilization.
x-risk frontier8.1B·9.080%12y$500.0B42
02
The largest controllable mortality risk is a primary-care delivery failure, not a missing drug.
welfare floor1.4B··77%5y·00
03
The AI compute buildout is no longer chip-constrained. It is power-constrained, and the gap is $1.3 trillion.
hard tech8.2B··30%12y$1.3T00
04
1.7 billion people need treatment for diseases that get under 2% of pharmaceutical R&D and falling aid.
welfare floor1.7B···10y·00
05
Close the gap between what materials cost and what buildings cost, housing is 5× its bill of materials.
hard tech1.6B8.0×·20%15y$2.0T53
06
Lift the ~700 million people living on less than $2.15 a day into stable prosperity.
welfare floor700.0M30.0×·40%··00
07
The US Surgeon General called it an epidemic. Mortality effect equivalent to smoking 15 cigarettes a day.
emerging1.5B5.0×·25%20y$50.0B40
08
2.3 million babies die in their first month of life every year, mostly from causes medicine already knows how to prevent.
welfare floor2.3M78.0×··5y·00
09
The Copenhagen Consensus welfare floor, pennies save lives, and we still are not spending them.
welfare floor2.5B48.0×·50%10y$150.0B50
10
Close Bloom's 2-sigma gap, every child deserves a personal tutor, and AI may finally make it tractable.
progress & abundance1.5B12.0×·30%12y$200.0B54
11
Decarbonize the global economy fast enough to limit warming, while keeping energy cheap and abundant.
welfare floor8.2B10.0×·50%··00
12
Every developed country is below replacement. Under-counted by EA and e/acc. Civilizationally large.
emerging6.0B·5.515%30y$1.0T42
13
Extend healthspan. Aging is the single largest driver of disease burden, and it is treatable.
hard tech8.1B7.0×·40%25y$300.0B83
14
Move value for everyone at near-zero cost, on rails not owned by a sixty-year-old duopoly.
progress & abundance1.3B··35%5y$1.0B00
15
Ideas are getting harder to find. Reverse the decline in research productivity per dollar.
progress & abundance8.1B20.0×6.535%20y$100.0B95
16
Produce clean, cheap, dispatchable energy at civilizational scale, fusion, advanced fission, geothermal.
hard tech8.1B15.0×7.025%25y$5.0T343
confidence dot on humans — high, med, low. full method in methodology.

The pipeline.

On optimism.fun, each ranked problem has thinkers explaining it, companies attacking it, and a coordination layer of talent and capital pointed at it. Every node is sourced.

05 · the white mirror

Every problem above, solved for all that have it.

Extreme poverty cut by more than half since 1990. Child mortality down ~60%. Literacy near-universal. Life expectancy up two decades. This is the world on the other side of the table — and the receipts are getting longer.

See the receipts →
06 · already happening

The market has already started pricing the solutions.

The world’s largest companies are already worth more than $100T combined — and most of that valuation traces back to a single quest: someone picked a hard problem and shipped a solution at scale. The leaderboard above ranks where the next dollar should go.

GDP growth has no physical ceiling — only a willingness ceiling. As long as we keep picking good problems and solving them, the curve compounds. Some quests are power-law: aligned AI, cheap fusion, disease eradication. Hit one and the whole table shifts up.

Weekly whitepaper drop

One problem.One whitepaper. Every week.

Each week we ship a deep-dive whitepaper on a top-ranked humanity-scale problem — built in the spirit of Musk’s Hyperloop Alpha and the transformer paper. Problem + market size + before/after vision + a proposed solution + the investors who would back it. Humanity’s Requests for Startups, sourced and sorted quantitatively. No spam. No marketing.

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