Humanity’s hardest problems.
Bring money or work.
19 problems. Every number sourced. Nothing for sale.
Problems
Pick a problem →
The biggest unsolved ones, ranked.
Capital
Fund a gap →
Where money is, and where it is missing.
Talent
Work on one →
Specific work that moves a problem.
The problems
| # | Problem | People | Related deaths / yr | |
|---|---|---|---|---|
| 1 | Diabetes | 589.0M | 1.6M | Act |
| 2 | Hypertension control | 1.4B | 19.2M | Act |
| 3 | COPD and chronic respiratory disease | 213.4M | 3.5M | Act |
| 4 | Cancer | 20.0M | 9.7M | Act |
| 5 | Neglected tropical diseases | 1.7B | — | Act |
| 6 | Extreme poverty | 700.0M | — | Act |
| 7 | Biosecurity & pandemic preparedness | 8.1B | 8.8M | Act |
| 8 | AI datacenter power | 8.2B | — | Act |
| 9 | Newborn survival | 2.3M | — | Act |
| 10 | Infectious disease (malaria, TB, HIV) | 2.5B | 2.5M | Act |
| 11 | Low-cost housing & construction | 1.6B | — | Act |
| 12 | Loneliness & social isolation | 1.5B | — | Act |
| 13 | Climate change | 8.2B | — | Act |
| 14 | Financial infrastructure | 1.3B | — | Act |
| 15 | Longevity & aging | 8.1B | 17.7M | Act |
| 16 | Pedagogy at scale | 1.5B | — | Act |
| 17 | Fertility decline & demographic stagnation | 6.0B | — | Act |
| 18 | Scientific productivity | 8.1B | — | Act |
| 19 | Energy abundance | 8.1B | — | Act |
Ranked by need against how well-served each problem is. Related deaths count every cause a problem feeds, so they overlap. How