Editor’s drop
Published 2026-08-27 · optimism.fun
blackpaper · the problem
whitepaper · the proposal
request for founders
Build the complete hypertension control loop for one accountable care network. Start with validated measurement, medicine availability, clinician-owned protocols, and 12-month control, not another wellness dashboard.
read the problem →The four-axis ranking
We rank humanity’s most important problems on four quantifiable dimensions — quantity of humans affected, severity per capita, current solution quality, and addressable market size — and package each as a proposal in the spirit of Musk’s Hyperloop Alpha. This document is the proposal for hypertension control. Every number below is sourced and tagged with confidence. Every ranking is a conjecture, open to refutation.
Quantity · humans affected
1.4B
highSeverity · WTP / wealth
1000000000%
medCurrent solutions
2.3 / 10
highWhat we are trying to solve
Hypertension is persistently high pressure in the arteries. It usually causes no symptoms while it damages blood vessels, the heart, brain, and kidneys, increasing the risk of heart attack, stroke, heart failure, chronic kidney disease, and dementia. WHO estimates that 1.4 billion adults aged 30 to 79 had hypertension in 2024, but only 320 million, 23 percent, had it controlled. The core interventions already exist: validated blood-pressure devices, standardized treatment protocols, inexpensive medicines, team-based primary care, reliable refills, and population registries. The unsolved problem is making that complete control loop dependable for every patient.
The gap between the world and the world that is physically possible
Today: 1.4B adults live with hypertension; about 600M are unaware and only 23% have it controlled. Measurement, medicines, follow-up, and data routinely fail as one disconnected chain.
Current solution quality is rated 2.3 / 10 (high confidence) — meaning there is substantial unclaimed ground between what exists and what is possible. WHO Hypertension fact sheet, 2025.
Who is already working on this
No companies have yet been tagged to this problem in the dataset. If you know one, open a PR.
If we solve this, here is the world we get
After · 10 years
Validated measurement, clinician-approved protocols, uninterrupted medicine supply, and active follow-up produce sustained majority control in every participating care network.
Section in progress
Technical specifications, architectural choices, and capital-stack design — the Hyperloop Alpha-equivalent depth — are being authored as the weekly cadence ships. New whitepaper sections ship with each Monday newsletter drop. Subscribe to get the upgrade, or contribute on GitHub.
What the market can pay
Section in progress
Addressable-market sizing for this problem is not yet in the dataset. New whitepaper sections ship with each Monday newsletter drop. Subscribe to get the upgrade, or contribute on GitHub.
What could go wrong, and how we know we are not wrong
Section in progress
Failure modes, ethical considerations, and the conditions under which this whitepaper would be falsified are being authored as the weekly cadence ships. The Deutschian commitment: every claim above is a conjecture; we publish the conditions under which we would update. New whitepaper sections ship with each Monday newsletter drop. Subscribe to get the upgrade, or contribute on GitHub.
Who would back this
Section in progress
No capital allocators have yet been tagged to this problem in the dataset. New whitepaper sections ship with each Monday newsletter drop. Subscribe to get the upgrade, or contribute on GitHub.
Where this is wrong, tell us
Every number on this page carries a source and a confidence tag. Every section open to refutation. If a citation is wrong, a number is stale, or a conjecture is unfounded — file a correction.
- [1] WHO Global report on hypertension 2025
- [2] WHO Hypertension fact sheet
- [3] WHO HEARTS technical package
- [4] WHO pharmacological treatment guideline
corrections → use the feedback widget in the nav · open issue at github.com/adamtpang/optimism.fun